Thrombocytes play important role in pathogenesis of diabetic vascular complications.
Aim: To study peculiarities of functional activity of thrombocytes in adolescents with diabetes mellitus type 1 (T1DM).
Patients and methods: 98 adolescents (42 boys, 56 girls) 12–16 y.o. with T1DM were examined. The duration of the disease was: less than 1 year in 25 patients (HbAc1 7.4±0.3%) – group 1, from 1 to 5 years in 40 patients (HbAc1 8.9±1.2%) – group 2, more then 5 years in 33 patients (HbAc1 10.3±1.7%) – group 3. Control group: 40 healthy adolescents 12-16 y.o. The indexes of trombocyte aggregation (degree, speed and time of aggregation) measured by laser method with different inductors (ADP, kollagen, adrenalin) and intravascular aggregation were evaluated.
Results: Levels of ADP- and adrenalin-stimulating aggregation, speed of kollagen-stimulating aggregation and intravascular aggregation of thrombocytes were increased in group 1 in comparance of control group (Cocoa Sneakers Paolo Dibrera Zanoli By P<0.05). Levels of ADP- and kollagen-stimulating aggregation (P<0.05) and intravascular aggregation (P<0.001) were also increased in group 2. Decrease of aggregation time was revealed in this group (P<0.05). Increase of all indexes of functional activity of thrombocytes (P<0.05) and increase of intravascular aggregation (P<0.001) were found in patients of group 3 in comparance of control group.
Conclusions: Functional activity of thrombocytes in adolescents with T1DM appeared to increase in correlation with duration of the disease and it may demand treatment with heparinoids.
Sneakers Dibrera Cocoa Zanoli By Paolo Barcelona, Spain
19 - 22 May 2018
By Zanoli Dibrera Paolo Sneakers Cocoa European Society of Endocrinology